Tissue Engineering of Small Diameter Vascular Grafts
نویسندگان
چکیده
منابع مشابه
Tissue engineering of small diameter vascular grafts.
Tissue engineering, using either polymer or biological based scaffolds, represents the newest approach to overcoming limitations of small diameter prosthetic vascular grafts. Their disadvantages include thromboembolism and thrombosis, anticoagulant related haemorrhage, compliance mismatch, neointimal hyperplasia, as well as aneurysm formation. This current review represents an overview about pr...
متن کاملTissue engineering of recellularized small-diameter vascular grafts.
A tissue-engineered small-diameter arterial graft would be of benefit to patients requiring vascular reconstructive procedures. Our objective was to produce a tissue-engineered vascular graft with a high patency rate that could withstand arterial pressures. Rat arteries were acellularized with a series of detergent solutions, recellularized by incubation with a primary culture of endothelial ce...
متن کاملTissue engineering of vascular grafts
Tissue engineering of vascular grafts 187 1 3 Summary Background There is a considerable clinical need for a sufficient prosthetic small-diameter substitute which can compete with autologous vessels. Currently used synthetic materials have a poor performance due to high thrombogeneicity and development of intimal hyperplasia. Tissue engineering is an interesting alternative approach for vascula...
متن کاملPolymer scaffolds for small-diameter vascular tissue engineering.
To better engineer small-diameter blood vessels, a few types of novel scaffolds were fabricated from biodegradable poly(L-lactic acid) (PLLA) by means of thermally induced phase separation (TIPS) techniques. By utilizing the differences in thermal conductivities of the mold materials, the scaffolds with oriented gradient microtubular structures in axial or radial direction were created using be...
متن کاملAntithrombogenic modification of small-diameter microfibrous vascular grafts.
OBJECTIVE To develop small-diameter vascular grafts with a microstructure similar to native matrix fibers and with chemically modified microfibers to prevent thrombosis. METHODS AND RESULTS Microfibrous vascular grafts (1-mm internal diameter) were fabricated by electrospinning, and hirudin was conjugated to the poly (L-lactic acid) microfibers through an intermediate linker of poly(ethylene ...
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ژورنال
عنوان ژورنال: European Journal of Vascular and Endovascular Surgery
سال: 2002
ISSN: 1078-5884
DOI: 10.1053/ejvs.2002.1654